基于太沙基极限承载力理论的管桩土塞高度计算方法

为分析开口管桩沉桩过程中产生的土塞效应,首先从土塞的形成过程和作用机理出发,建立了土塞单元体的受力平衡方程,得出了垂直向总荷载的表达式;其次,将土塞视为"桩中桩",基于太沙基桩端极限承载力理论,得出"桩中桩"桩端极限承载力的表达式,从而导得管桩在沉桩过程中土塞高度的表达式;最后,将本文理论计算结果与工程实例进行对比分析,并进一步分析了径厚比、土的黏聚力以及桩土表面粗糙度对管桩沉桩过程中形成的土塞高度的影响,得出结论:同一入土深度,土塞高度随着径厚比增大而增大,随着桩土表面粗糙度的增加而减小,而土的黏聚力对土塞高度的影响不大.结果表明本文计算方法是基本可行的,对开口管桩沉桩过程中土塞高度的预测计算具有一定的参考价值.     

ID-Based Public Auditing Protocol for Cloud Storage Data Integrity Checking with Strengthened Authentication and Security

Cloud storage service reduces the burden of data users by storing users’ data files in the cloud. But, the files might be modified in the cloud. So, data users hope to check data files integrity periodically. In a public auditing protocol, there is a trusted auditor who has certain ability to help users to check the integrity of data files. With the advantages of no public key management and verification, researchers focus on public auditing protocol in ID-based cryptography recently. However, some existing protocols are vulnerable to forgery attack. In this paper, based on ID-based signature technology, by strengthening information authentication and the computing power of the auditor, we propose an ID-based public auditing protocol for cloud data integrity checking. We also prove that the proposed protocol is secure in the random oracle model under the assumption that the Diffie-Hellman problem is hard. Furthermore, we compare the proposed protocol with other two ID-based auditing protocols in security features, communication efficiency and computation cost. The comparisons show that the proposed protocol satisfies more security features with lower computation cost.     

基于时空频特征融合的距离-速度复合欺骗干扰识别技术研究

针对距离-速度复合欺骗干扰信号形式复杂及识别难度大的特点,提出了一种基于时空频特征融合的距离-速度复合欺骗干扰识别算法。首先,分析真实目标和虚假目标在空域、频域和时域的特征差异;然后,针对真假目标在不同域的特征区别,分别提取回波点迹的空域特征和频域特征;最后,将提取的空域及频域特征在时域进行融合,采用先积累后判别和基于二进制检测两种特征融合方法,利用时空频融合特征对距离-速度复合欺骗干扰进行判决。仿真结果表明,该算法能够对距离-速度复合欺骗干扰进行有效的识别。     

Attack and Defense Strategies in Complex Networks Based on Game Theory

To investigate the attack and defense strategies in complex networks, the authors propose a two-player zero-sum static game model with complete information which considers attack and defense strategies simultaneously. The authors assume that both the attacker and defender have two typical strategies: Targeted strategy and random strategy. The authors explore the Nash equilibriums of the attacker-defender game and demonstrate that when the attacker's attack resources are not so significantly abundant as the defender's resources, there exists a pure-strategy Nash equilibrium in both model networks and real-world networks, in which the defender protects the hub targets with large degrees preferentially, while the attacker prefers selecting the targets randomly. When the attack resources are much higher than defense resources, both the attacker and the defender adopt the targeted strategy in equilibriums. This paper provides a new theoretical framework for the study of attack and defense strategies in complex networks.     

离散型二维竞争系统中某群体消亡的条件

研究了离散型二维竞争系统的渐近稳定性,得到了这类竞争系统中各类平衡点的坐标及其性质,获得了系统在边界上的平衡点处渐近稳定的一系列充分条件.这些条件等价于该系统中的某个群体在竞争过程中消亡或被淘汰的相应条件.     

Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M

The protein kinase D (PKD) family of proteins are important regulators of tumor growth, development, and progression. CRT0066101, an inhibitor of PKD, has antitumor activity in multiple types of carcinomas. However, the effect and mechanism of CRT0066101 in bladder cancer are not understood. In the present study, we show that CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. We also demonstrate that CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. To further assess the role of PKD in bladder carcinoma, we examined the three PKD isoforms and found that PKD2 was highly expressed in eight bladder cancer cell lines and in urothelial carcinoma tissues from the TCGA database, and that short hairpin RNA (shRNA)-mediated knockdown of PKD2 dramatically reduced bladder cancer growth and invasion in vitro and in vivo, suggesting that the effect of the compound in bladder cancer is mediated through inhibition of PKD2. This notion was corroborated by demonstrating that the levels of phospho-PKD2 were markedly decreased in CRT0066101-treated bladder tumor explants. Furthermore, our cell cycle analysis by flow cytometry revealed that CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27^Kip1 and phospho-CDK1 (Thr14/Tyr15). Moreover, CRT0066101 downregulated the expression of Cdc25C, which dephosphorylates/activates CDK1, but enhanced the activity of the checkpoint kinase Chk1, which inhibits CDK1 by phosphorylating/inactivating Cdc25C. Finally, CRT0066101 was found to elevate the levels of Myt1, Wee1, phospho-Cdc25C (Ser216), Gadd45α, and 14-3-3 proteins, all of which reduce the CDK1-cyclin B1 complex activity. These novel findings suggest that CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression.     

An Additive-Multiplicative Cox-Aalen Subdistribution Hazard Model for Competing Risks Data

This paper proposes a flexible additive-multiplicative Cox-Aalen hazard model which allows time-varying covariate effects for the subdistribution in a competing risks study. Weighted estimating equation approaches under an covariates-dependent adjusted weight by fitting the Cox proportional hazard model for the censoring distribution are established for inference on the model parametric and nonparametric components. In addition, large number properties are presented and the finite sample behavior of the proposed estimators is evaluated through simulation studies, estimators from the proposed method perform satisfactorily on reduction of the bias. The authors apply our model to a competing risks data set from a tamoxifen trail for breast cancer study.     

毛花猕猴桃果实发育过程中理化性质的变化研究

为深入了解猕猴桃果实生长发育规律及果实商品价值,本研究以四川地区野生毛花猕猴桃果实为材料,采用田间取样和实验室测定相结合的方法测定其果实发育过程中理化性质变化.结果显示果实重量、纵横径和干物质积累呈单‘S’型曲线.果实淀粉积累时间短,果糖和葡萄糖从盛花期(DAA)105 d开始急剧上升,果实成熟时生成少量的蔗糖和麦芽糖.苹果酸和柠檬酸浓度整体呈上升趋势,而奎宁酸在90 DAA前保持相对恒定,105 DAA时下降到最低,后保持稳定.VC含量高,整体呈下降趋势.以上结果说明毛花猕猴桃果树园艺性状好,其果实有机酸含量高,特别是VC,是天然维生素库.     

半潜式钻井平台螺旋桨修复技术的应用研究进展

针对半潜式海洋钻井平台推进器螺旋桨面临的空泡腐蚀、电化学腐蚀以及海洋生物附着污损等问题，综述了焊接、粘接、热喷涂、冷喷涂修复技术的应用研究进展。认为目前的螺旋桨修复再制造技术普遍存在着修复层应力集中、结合强度低、孔隙率高、高温导致材料变性等缺陷，今后的研究工作应向着避免应力集中、增大修复层结合强度、降低作业温度、减小孔隙率的方向发展，以期能够制备更加致密均匀的修复层。     

The Life-Cycle Model with Optimal Retiring Age and Simulation

In this paper, a life-cycle model with retirement is set up to study how an individual chooses the optimal retiring age on account of wage growth rate, longevity and healthy state. It is proved that there exists optimal retiring age under given conditions. The numerical simulations are given to show how wage growth rate, longevity and healthy state affect retiring age.